Description
FOXO4-DRI (Retro-Inverso)
FOXO4-DRI (Retro-Inverso) is a synthetic, research-grade peptide engineered to mimic and inhibit the native FOXO4 protein, a key regulator in cellular aging pathways. This modified version of FOXO4 incorporates a retro-inverso structure, which not only enhances its stability and half-life in biological systems but also improves its ability to penetrate cells and interact with target proteins effectively.
At the core of FOXO4-DRI’s mechanism is its interference with the interaction between FOXO4 and p53—a protein complex that plays a critical role in maintaining cellular senescence. By disrupting this interaction, FOXO4-DRI enables the selective elimination of senescent cells through apoptosis. These aged, dysfunctional cells are known to accumulate in tissues over time and contribute to chronic inflammation, tissue degradation, and the onset of age-related diseases.
Preclinical studies have demonstrated that FOXO4-DRI effectively clears senescent cells, resulting in enhanced tissue regeneration, improved organ function, and a reversal of biological markers of aging. Its actions extend beyond senescence clearance: FOXO4-DRI also modulates insulin signaling, cell cycle regulation, and oxidative stress pathways—three key factors in longevity and metabolic health.
Due to its targeted mechanism and systemic benefits observed in animal studies, FOXO4-DRI is currently being explored as a potential therapeutic candidate in age-related research, regenerative medicine, and advanced anti-aging interventions.
Key Features:
- Synthetic retro-inverso peptide for enhanced stability and cell penetration
- Disrupts FOXO4-p53 interaction to induce apoptosis in senescent cells
- Promotes tissue rejuvenation and organ function in preclinical studies
- Influences insulin signaling, oxidative stress, and cell cycle regulation
- Investigational compound for anti-aging and longevity research
